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THE DISCIPLINE OF EPIDEMIOLOGY IS ABOUT MASTERING THE CONCEPT OF CONFOUNDING. Applying multiple queue, this 324-page effort mathematically describes a variety of approaches and designs that escalate the vigor of non-randomized comorbidity research in relatively small samples: marginal and hierarchical models, Markov chain Monte Carlo iterates, stochastic compartmental simulations, and elliptical regression. The theory chapter is followed by presentation of the author's own twelve meta-studies.